Legends of Runeterra

Legends of Runeterra is a free-to-play digital collectible card game developed by Riot Games and set in the world of League of Legends. Players build decks around champions and regions drawn from League lore, dueling in a back-and-forth turn system that emphasizes reactive, interactive play. It distinguishes itself from other card games with a generous, low-cost progression model that lets players earn cards without heavy spending. Strategic depth comes from alternating attack and defense priority and timing spells precisely. As a competitive card game it sits apart from the single-player roguelikes on this list, though it also offers a roguelike PvE mode.

Path of Champions is the PvE mode that lets players assume and earn new heroes with their own decks. You build your decks along a route of increasingly difficult challenges to earn rewards, unlock new heroes, cards, and other cosmetic rewards.

Riot has supported it with regular expansions and lore-rich content.